Brain regions with abnormal network properties in severe epilepsy of Lennox-Gastaut phenotype: Multivariate analysis of task-free fMRI

M Pedersen; EK Curwood; JS Archer; DF Abbott; GD Jackson

Journal article

Brain regions with abnormal network properties in severe epilepsy of Lennox-Gastaut phenotype: Multivariate analysis of task-free fMRI

M Pedersen, EK Curwood, JS Archer, DF Abbott, GD Jackson

Epilepsia | WILEY | Published : 2015

DOI: 10.1111/epi.13135

Abstract

Objective Lennox-Gastaut syndrome, and the similar but less tightly defined Lennox-Gastaut phenotype, describe patients with severe epilepsy, generalized epileptic discharges, and variable intellectual disability. Our previous functional neuroimaging studies suggest that abnormal diffuse association network activity underlies the epileptic discharges of this clinical phenotype. Herein we use a data-driven multivariate approach to determine the spatial changes in local and global networks of patients with severe epilepsy of the Lennox-Gastaut phenotype. Methods We studied 9 adult patients and 14 controls. In 20 min of task-free blood oxygen level-dependent functional magnetic resonance imagin..

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University of Melbourne Researchers

David Abbott Author

John Archer Author

Graeme Jackson Author

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by NHMRC

Funding Acknowledgements

This study was supported by the National Health and Medical Research Council (NHMRC) of Australia (program grant 628952; project grant 628725). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. G Jackson is supported by an NHMRC practitioner fellowship (1060312). M Pedersen is supported by The University of Melbourne scholarships (MIRS & MIFRS).